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Carlos del Carpio Department of Ecological Engineering Toyohashi University of Technology Japan |
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The intimate dependence of bio-macromolecular function on the molecule structure, which itself is the result of a complex folding process, makes, however, the problem of automatically predicting bio-molecular interaction of@ particular difficulty and together with the problem of macromolecular@structure prediction constitutes a major problem in the post-genome era.
The present talk deals with new bio-informatic techniques directed to solve those problems in modern molecular biology, and their applications to processes of molecular recognition and drug design. The former oriented to elucidate the interactions triggering several bio-organic processes in living organisms and the latter to assist rational processes of drug design, which synergistically with the sequencing of the genomes of several other organisms may assist in the foundation of tailor made treatment to the several diseases affecting human beings.
After obtaining the bachelor's degree in Chemical Engineering at the National University of Saint Anthony in Cusco-Peru, the speaker performed research on petrochemical products at the Peruvian National Petroleum Company. Then obtained a Master's degree in Nuclear Engineering while working at the Peruvian Institute of Nuclear Energy, researching on radiological preservation of food.
He was awarded a prestigious Mombusho Scholarship to perform studies on Chemical Information in Japan and obtained a second master's degree to then pursue further specialization @in Computer Chemistry and obtain the degree of Dr. in Engineering.
He continued research in Academia at Toyohashi University of Technology as Assistant Professor, at the Department of Knowledge Based Information. Three years later was promoted to Aux. Professor, and worked at the same department as head of the Laboratory for Information and AI in Molecular and Biological Sciences.
From 1996 to date he works at the Department of Ecological Engineering as head of the Laboratory for Bioinformatics.
His research activities involve a gamma of applications of information technologies to computer simulation of organic systems and in general to problem solution in the life sciences.
Some of them involve the development of an automatic system for chemical structure elucidation, which was incorporated into the more general system CHEMICS. He was involved in the development of the system for chemical reaction prediction and organic@synthesis planning: AIPHOS (Artificial Intelligence for Planning and handling Organic synthesis).
From 1991, he performs studies on computer assisted drug design, prediction of the tertiary @structure of Proteins and RNA, and recently he has developed a system for Bio-macromolecular Interaction Assessment MIAX, which is one of the main topics of his presentation. [an error occurred while processing this directive]